Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

2.6K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.6K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

8.3K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.3K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

8.0K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
8.0K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

928
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
928
GPI Anchoring of Proteins in the ER Membrane01:29

GPI Anchoring of Proteins in the ER Membrane

5.1K
GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
5.1K
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

9.9K
Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adenovirus holds the platelet in flow.

Blood·2025
Same author

Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS.

Blood advances·2025
Same author

Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk.

Nature communications·2024
Same author

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module.

Blood·2024
Same author

Platelet size matters.

Blood·2024
Same author

Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller.

Nature communications·2024

Related Experiment Video

Updated: Dec 13, 2025

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.1K

Structure-function of platelet glycoprotein Ib-IX.

M Edward Quach1, Renhao Li1

  • 1Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.

Journal of Thrombosis and Haemostasis : JTH
|August 1, 2020
PubMed
Summary

The glycoprotein (GP)Ib-IX complex is crucial for platelet function and hemostasis. Recent research reveals new insights into its organization, activation, and diverse roles in platelet biology.

Keywords:
glycoprotein Ibmechanoreceptorplateletthrombocytopeniathrombosis

More Related Videos

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

683
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

18.5K

Related Experiment Videos

Last Updated: Dec 13, 2025

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.1K
An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

683
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

18.5K

Area of Science:

  • Hematology
  • Molecular Biology
  • Biochemistry

Background:

  • The glycoprotein (GP)Ib-IX receptor complex is essential for platelet adhesion and primary hemostasis.
  • It mediates platelet arrest at vascular injury sites through interaction with von Willebrand factor (VWF).
  • Its role extends to other platelet biology processes involving various ligands and counter-receptors.

Purpose of the Study:

  • To review recent critical advances in the understanding of the GPIb-IX complex.
  • To summarize key findings regarding its organization, dynamics, activation, regulation, and functions.
  • To identify outstanding questions in the field of platelet mechanoreceptor complex research.

Main Methods:

  • Literature review of recent scientific findings.
  • Synthesis of information on GPIb-IX complex structure and function.
  • Identification of knowledge gaps and future research directions.

Main Results:

  • Significant progress has been made in understanding the GPIb-IX complex's organization and dynamics.
  • New insights into the activation, regulation, and diverse functions of this receptor complex have emerged.
  • The complex's role as a unique platelet mechanoreceptor is increasingly recognized.

Conclusions:

  • The GPIb-IX complex is a dynamic and multifaceted receptor crucial for platelet physiology.
  • Despite decades of research, many aspects of its function and regulation require further investigation.
  • Continued research promises to uncover novel therapeutic targets for bleeding disorders and thrombosis.