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Updated: Dec 13, 2025
Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat
Published on: June 26, 2019
Behavioral testing in animal models of spinal cord injury
1University of Alberta, Faculty of Rehabilitation Medicine, Dept of Physical Therapy, 3-48 Corbett Hall, Edmonton T6G 2G4, Canada; University of Alberta, Neuroscience and Mental Health Institute, 2-132 Li Ka Shing, Edmonton T6G 2E1, Canada.
Abstract:
This review is based on a lecture presented at the Craig H. Neilsen Foundation sponsored Spinal Cord Injury Training Program at Ohio State University. We discuss the advantages and challenges of injury models in rodents and theory relation to various behavioral outcome measures. We offer strategies and advice on experimental design, behavioral testing, and on the challenges, one will encounter with animal testing. This review is designed to guide those entering the field of spinal cord injury and/or involved with in vivo animal testing.
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