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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: Dec 13, 2025

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
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Isolation of Precursor B-cell Subsets from Umbilical Cord Blood

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Guidelines for Cord Blood Unit Selection.

Ioannis Politikos1, Eric Davis1, Melissa Nhaissi1

  • 1Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|August 1, 2020
PubMed
Summary
This summary is machine-generated.

Selecting the best cord blood unit is key for successful engraftment and survival in cord blood transplantation. This review offers guidelines on cell dose, HLA matching, and unit quality for optimal graft selection.

Keywords:
CB unit selectionCD34+ cell doseHLA matchTNC dose

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Area of Science:

  • Hematology
  • Transplantation Immunology
  • Cellular Therapy

Background:

  • Cord blood unit selection is crucial for successful cord blood transplantation (CBT).
  • Selection involves complex factors: cell dose, human leukocyte antigen (HLA) match, and unit quality.
  • Optimal unit selection maximizes engraftment and patient survival.

Purpose of the Study:

  • To provide comprehensive, evidence-based guidelines for cord blood unit selection in CBT.
  • To detail criteria for evaluating unit progenitor cell content and engraftment potential.
  • To outline practical steps for cord blood searches and graft selection.

Main Methods:

  • Review of evidence-based and experience-based guidelines for cord blood unit selection.
  • Analysis of criteria for total nucleated cell (TNC) and CD34+ cell dose.
  • Evaluation of HLA matching (6-locus and 8-allele) and unit quality determinants.

Main Results:

  • Defines acceptable TNC and CD34+ cell dose criteria for single and double unit grafts.
  • Specifies acceptable HLA matching criteria for donor-recipient pairs.
  • Discusses evaluation of donor-specific HLA antibodies and unit quality factors.

Conclusions:

  • Comprehensive guidelines are essential for optimal cord blood unit selection.
  • Consideration of cell dose, HLA match, and unit quality is critical for CBT success.
  • A practical approach to cord blood searches and graft selection improves outcomes.