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A novel embolic microspheres with micro nano binary progressive structure for transarterial chemoembolization

Li Wei-Ze1, Han Wen-Xia2, Zhao Ning1

  • 1College of Pharmacy, Xi'an Medical University, Xi'an 710021, PR China.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|August 1, 2020
PubMed
Summary

Novel micro-nano binary microspheres (MN-Ms) show promise for transarterial chemoembolization (TCE) in liver cancer. These MN-Ms effectively deliver chemotherapy agents to tumors, enhancing treatment efficacy and reducing side effects.

Keywords:
Binary progressive structureBletilla striata polysaccharideLiver cancerMicrospheresNano flexible liposomesSodium dimethyl-cantharidateTransarterial chemoembolization

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Area of Science:

  • Biomaterials Science
  • Oncology
  • Nanotechnology

Background:

  • Transarterial chemoembolization (TCE) is a key treatment for liver cancer.
  • Developing effective embolic agents is crucial for improving TCE outcomes.
  • Current agents face challenges in drug delivery and targeting.

Purpose of the Study:

  • To develop novel embolic microspheres with a micro-nano binary progressive structure (MN-Ms).
  • To evaluate the potential of MN-Ms for transarterial chemoembolization (TCE) in liver cancer treatment.

Main Methods:

  • Fabrication of MN-Ms using an emulsion crosslinking method.
  • Characterization of MN-Ms for structural, swelling, and suspensibility properties.
  • In vitro evaluation of drug delivery and cytotoxicity against hepatoma cells.

Main Results:

  • MN-Ms possess a unique micro-nano binary progressive structure.
  • The microspheres exhibited ideal round shape, swelling, and suspensibility for embolization.
  • MN-Ms demonstrated effective site-specific drug delivery and enhanced cytotoxicity to liver cancer cells.

Conclusions:

  • MN-Ms are a promising novel embolic agent for TCE applications.
  • The unique structure facilitates targeted drug delivery and enhances anti-cancer effects.
  • This technology holds potential for advanced liver cancer treatment.