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Updated: Dec 13, 2025
Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
miR-137: A Novel Therapeutic Target for Human Glioma
Yajun Wang1, Riling Chen2, Xia Zhou3
1Maternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, China; Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China; Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Abstract:
MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. In addition, we focus on the identified miR-137 targets and pathways in the occurrence and development of glioma. Finally, future implications for the diagnostic and therapeutic potential of miR-137 in glioma were discussed.
Insights
MicroRNA-137 (miR-137) is vital in glioma development and prognosis. This review details miR-137's role in cancer progression and its potential as a diagnostic and therapeutic target for glioma.
Area of Science:
- Neuroscience
- Oncology
- Molecular Biology
Background:
- MicroRNA-137 (miR-137) is significantly expressed in the brain.
- Glioma, a primary brain tumor, is influenced by miR-137 in its development and patient outcomes.
Purpose of the Study:
- To review current research on miR-137's function in glioma.
- To explore miR-137 targets and pathways involved in glioma.
- To discuss the diagnostic and therapeutic potential of miR-137 in glioma.
Main Methods:
- Literature review of studies on miR-137 and glioma.
- Analysis of miR-137's involvement in key cancer processes: apoptosis, proliferation, migration, invasion, angiogenesis, and drug resistance.
- Identification of miR-137 molecular targets and signaling pathways.
Main Results:
- miR-137 impacts multiple facets of glioma progression, including cell death, growth, and spread.
- Specific molecular targets and pathways regulated by miR-137 in glioma have been identified.
- miR-137 influences the response of glioma cells to cancer therapies.
Conclusions:
- miR-137 is a critical regulator in glioma pathogenesis.
- Understanding miR-137's mechanisms offers insights into glioma biology.
- miR-137 holds promise as a biomarker and therapeutic agent for glioma treatment.
