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Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Related Experiment Video

Updated: Dec 13, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

Clonal hematopoiesis and risk for hematologic malignancy.

Julia T Warren¹, Daniel C Link²

¹Division of Hematology-Oncology, Department of Pediatrics and.

|August 1, 2020

Summary

This summary is machine-generated.

Clonal hematopoiesis (CH) increases cancer risk in older adults. Specific genetic mutations and stressors can predict progression to myeloid malignancies like leukemia, aiding early detection.

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Area of Science:

Hematology
Oncology
Genetics

Background:

Clonal hematopoiesis (CH) is prevalent in aging populations.
CH is linked to an elevated risk of developing hematologic cancers.

Purpose of the Study:

To review the association between CH and hematopoietic malignancy.
To identify CH features predicting leukemic progression.
To explore the role of hematopoietic stressors in CH evolution to myeloid malignancies.

Main Methods:

Review of existing studies on CH and hematologic cancer.
Analysis of predictive features for leukemic transformation.
Investigation of hematopoietic stressors' impact on CH progression.

Main Results:

CH from mutations/variants increases malignancy risk tenfold.
High-risk CH features include TP53/spliceosome mutations, high variant allele fraction, multiple mutations, and abnormal blood indices.
CH with cytopenias indicates a high risk of myeloid malignancy progression.

Conclusions:

Certain CH characteristics and peripheral blood cytopenias signify a high risk for myeloid malignancy.
Hematopoietic stressors like genotoxic exposure and inflammation may drive CH to leukemia.
Predictive models integrating CH features and stressors could prevent hematologic malignancies.