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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

The thrombin-inflammation axis in cancer progression.

Rachel Cantrell¹, Joseph S Palumbo¹

¹Cancer and Blood Diseases Institute, The Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Thrombosis Research

|August 2, 2020

Summary

Inflammation and the hemostatic system, crucial for wound healing, surprisingly drive cancer progression. Understanding their crosstalk reveals new therapeutic targets for cancer treatment and prevention.

Keywords:

Hemostatic factors Inflammation Malignancy

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Published on: February 26, 2019

Area of Science:

Oncology
Immunology
Hematology

Background:

Cancer progression involves complex interactions between tumor cells and host factors.
Inflammatory and hemostatic systems are key host-derived factors influencing cancer.
Chronic inflammation is linked to major cancers like colon, pancreatic, prostate, and breast adenocarcinoma.

Purpose of the Study:

To review the crosstalk between inflammation and hemostasis in cancer.
To elucidate how these systems cooperatively promote malignancy.
To identify novel therapeutic targets by dissecting these mechanisms.

Main Methods:

Literature review focusing on inflammation-hemostasis interplay in cancer.
Analysis of mechanisms involving inflammatory cells, thrombin-fibrinogen axis, and protease-activated receptor-1.
Synthesis of current knowledge on the role of these systems in tumorigenesis, growth, and metastasis.

Main Results:

Inflammation and hemostasis exhibit bidirectional crosstalk, essential for normal functions but co-opted by cancer.
This interplay promotes multiple stages of cancer, including initiation, growth, and metastasis.
Specific interactions involve inflammatory cells activating hemostasis and hemostatic components regulating inflammation.

Conclusions:

The integrated inflammatory and hemostatic systems significantly contribute to cancer pathobiology.
Dissecting these cooperative mechanisms fills knowledge gaps in cancer understanding.
Targeting the inflammation-hemostasis axis offers potential for novel cancer therapies.