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Updated: Dec 13, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Non-neoplastic colorectal disease biopsies: evaluation and differential diagnosis
Michelle Moore1, Roger M Feakins2, Gregory Y Lauwers3
1Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK.
Abstract:
A wide variety of non-neoplastic conditions may be encountered on colorectal biopsy encompassing idiopathic, infectious, vascular and immune-mediated aetiologies. Although interpretation of such biopsies may be challenging, appreciation of the dominant pattern of injury and subsequent host response may allow for a more focused histological diagnosis in the correct clinical and endoscopic setting. This article aims to provide a systematic, methodical approach to the assessment of such biopsies, concentrating mainly on diagnoses other than inflammatory bowel disease.
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