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Wirsungocele: evaluation by MRCP and clinical significance
Sehnaz Evrimler1,2, Jordan K Swensson1, Mazhar Soufi3
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N University Blvd Room 0663, Indianapolis, IN, 46202, USA.
Purpose:
Wirsungocele is a rare cystic dilatation of the main pancreatic duct seen at the terminal portion of the duct of Wirsung. The purpose of our study is to evaluate the diagnostic value of MRCP in detection of Wirsungocele and the association between the MRCP-determined size of Wirsungocele and the MRCP-clinical findings of pancreatitis.
Methods:
Thirty-four patients with reported 'Wirsungocele' were analyzed in the study. Two radiologists reviewed MRCP/S-MRCP images for the presence and diameter of Wirsungocele (WD), main pancreatic duct dilatation (MPDD), side branch ectasia (SBE), acinarization, and duodenal filling grade. Electronic medical record review included symptoms (abdominal pain), signs (recurrent acute/chronic pancreatitis), and select laboratory testing (serum amylase and lipase). Inter-reader agreement values were calculated by ICC. Pearson correlation analysis was performed to evaluate the association of WD with radiological and clinical findings. The comparison of WD on MRCP versus S-MRCP was calculated by Wilcoxon test. Mann-Whitney U test was used for two independent variable comparisons.
Results:
The sensitivity of MRCP for the detection of Wirsungocele calculated using the S-MRCP and ERCP as the reference method was 76.9% and 100%, respectively. There was a significant difference in the diameter of Wirsungocele measured by MRCP vs S-MRCP (p < 0.001). There was good inter-reader agreement for the detection of Wirsungocele on MRCP and measurement of WD on MRCP and S-MRCP (ICC: 0.79, 0.89, and 0.80, respectively, p < 0.001). There was a significant difference in WD between the patients with and without MPDD (p < 0.05). There was a significant positive correlation between WD and MPDD (r = 0.66, p < 0.05). WD was significantly associated with recurrent acute pancreatitis (p < 0.05).
Conclusion:
MRCP is a highly sensitive and non-invasive imaging tool for detection of Wirsungocele. Greater Wirsungocele diameter is associated with MPDD and recurrent acute pancreatitis.
Insights
Magnetic Resonance Cholangiopancreatography (MRCP) effectively detects Wirsungocele, a rare pancreatic duct dilatation. Larger Wirsungocele size correlates with main pancreatic duct dilatation and recurrent acute pancreatitis, aiding clinical management.
Area of Science:
- Radiology
- Gastroenterology
- Medical Imaging
Background:
- Wirsungocele is a rare cystic dilatation of the main pancreatic duct.
- Accurate diagnosis and understanding its associations are crucial for patient management.
Purpose of the Study:
- To evaluate the diagnostic value of MRCP in detecting Wirsungocele.
- To assess the association between MRCP-determined Wirsungocele size and clinical findings of pancreatitis.
Main Methods:
- Retrospective analysis of 34 patients with reported Wirsungocele.
- Review of MRCP/S-MRCP images for Wirsungocele diameter and associated pancreatic duct changes.
- Correlation of imaging findings with clinical data including pancreatitis history and symptoms.
Main Results:
- MRCP demonstrated a sensitivity of 76.9% for Wirsungocele detection compared to ERCP.
- Significant differences in Wirsungocele diameter were noted between MRCP and S-MRCP.
- A positive correlation was found between Wirsungocele diameter, main pancreatic duct dilatation, and recurrent acute pancreatitis.
Conclusions:
- MRCP is a sensitive, non-invasive tool for Wirsungocele detection.
- Increased Wirsungocele diameter is linked to main pancreatic duct dilatation and recurrent acute pancreatitis.
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