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Updated: Dec 13, 2025
18:57
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
47.0K
Ion Transport and Radioresistance
Bastian Roth1, Stephan M Huber2
1Department of Biology, Neurophysiology and Neurosensory Systems, Technische Universität Darmstadt, Darmstadt, Germany.
Reviews of Physiology, Biochemistry and Pharmacology
|August 2, 2020
Summary
Ion transport alterations in tumor cells are key to cancer progression and therapy resistance. Ion transport processes induced by ionizing radiation significantly impact radioresistance and treatment outcomes.
Area of Science:
- Oncology
- Cell Biology
- Radiation Biology
Background:
- Neoplastic transformation involves altered ion transport across cell membranes.
- These changes influence cancer cell adaptation, progression, metastasis, and therapy resistance.
Purpose of the Study:
- To review ion transport processes in tumor cells induced by ionizing radiation.
- To discuss their role in radioresistance and therapy failure.
Main Methods:
- Literature review of ion transport mechanisms in cancer.
- Focus on radiogenic ion transports across plasma and mitochondrial membranes.
Main Results:
- Ion transport alterations are critical for phenotypical reprogramming of cancer cells.
- Radiogenic ion transports impact cell cycle, DNA repair, metastasis, and hypoxia adaptation.
- These processes contribute to reactive oxygen species formation.
Conclusions:
- Ion transport modulation is a significant factor in tumor radioresistance.
- Understanding these mechanisms is crucial for improving cancer therapy outcomes.
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