Related Experiment Video
Updated: Dec 13, 2025
Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
Published on: October 25, 2015
Reference intervals for serum amyloid A, haptoglobin, ceruloplasmin, and fibrinogen in apparently healthy neonatal
Ceren Dinler1, Gulten Emek Tuna1, Erhan Ay1
1Department of Internal Medicine, Veterinary Faculty, Adnan Menderes University, Aydın, Turkey.
Insights
This study establishes reference intervals for acute-phase proteins in neonatal Kivircik lambs, crucial for health monitoring. These findings aid in diagnosing and managing health status in young lambs.
Area of Science:
- Veterinary Clinical Pathology
- Animal Biochemistry
- Neonatal Lamb Care
Background:
- Acute-phase proteins (APPs) are vital biomarkers for diagnosing, prognosing, and monitoring animal health.
- Establishing reference intervals (RIs) is essential for accurate laboratory diagnostics and clinical decision-making.
- RIs for APPs in neonatal lambs are currently lacking, hindering effective veterinary care.
Purpose of the Study:
- To determine the reference intervals (RIs) for serum amyloid A (SAA), haptoglobin (Hp), ceruloplasmin (Cp), and fibrinogen (Fb) in neonatal cross-bred Kivircik lambs.
- To provide essential diagnostic benchmarks for neonatal lamb health assessment.
Main Methods:
- Blood samples were collected from 42 neonatal cross-bred Kivircik lambs at multiple time points (0-28 days).
- Concentrations of SAA, Hp, Cp, and Fb were measured using established veterinary clinical pathology methods.
- Age- and sex-related effects on APP concentrations were analyzed.
Main Results:
- Reference interval for serum haptoglobin (Hp) was determined as 0-0.4 g/L, with no significant age or sex influence.
- Serum amyloid A (SAA), ceruloplasmin (Cp), and fibrinogen (Fb) showed significant age- and sex-related variations, with specific elevated periods noted.
- SAA levels were higher in the first week, while Cp and Fb peaked around 14-21 days of age.
Conclusions:
- This study provides the first established reference intervals for key acute-phase proteins in neonatal lambs.
- The determined RIs are valuable for clinical decision-making in cross-bred Kivircik lambs during the critical neonatal period.
- These findings support improved health monitoring and disease management in neonatal sheep.
Background:
Acute-phase proteins (APPs) are considered biomarkers for diagnoses, prognoses, and treatment and health status monitoring. Reference intervals (RIs) are an integral part of diagnostic laboratory testing and clinical decision-making. The RIs for neonatal lambs are lacking.
Objective:
This study aimed to determine the RIs of serum amyloid A (SAA), haptoglobin (Hp), ceruloplasmin (Cp), and fibrinogen (Fb) concentrations in neonatal cross-bred Kivircik lambs.
Methods:
The study consisted of 42 neonatal cross-bred Kivircik lambs. Physical examinations were performed daily, and blood samples were collected at 0 (precolostrum), 1, 3, 7, 14, 21, and 28 days of age. The RIs of SAA, Hp, Cp, and Fb concentrations were calculated according to the recommendation of the American Society for Veterinary Clinical Pathology. Results were also evaluated for age- and sex-related effects.
Results:
The RI for serum Hp was 0-0.4 g/L, and no apparent effect of age or sex was noted. Because of significant age- and sex-related differences, the SAA (0.34-55.12 µg/mL), Cp (2.4-26.07 mg/mL), and Fb (218.86-527.82 mg/mL) results were given as minimum and maximum values. Serum SAA on the 1st, 3rd, and 7th days of life, and Cp and Fb concentrations on the 14th and 21st days of life, were significantly higher than those on other study days.
Conclusions:
This study is the first to establish RIs for neonatal lambs, and the values obtained could be useful for making clinical decisions regarding cross-bred Kivircik lambs during this critical period.
More Related Videos
08:58Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
13:00Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
Published on: July 31, 2021