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Related Experiment Video

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Nox2 activation in Covid-19.

Francesco Violi1, Alessandra Oliva2, Roberto Cangemi3

  • 1Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.

Redox Biology
|August 2, 2020
PubMed
Summary

Nox2 activation, measured by soluble Nox2-derived peptide (sNox2-dp), is linked to severe COVID-19 and thrombotic events. Higher sNox2-dp levels were observed in COVID-19 patients, particularly those with severe disease or blood clots.

Keywords:
Covid-19NADPH oxidaseNox-2Thrombosis

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Area of Science:

  • Biomedical Research
  • Cardiovascular Science
  • Infectious Disease

Background:

  • Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2) contributes to artery dysfunction through reactive oxygen species production.
  • While RNA viruses can activate Nox2, its role in coronavirus 2019 (COVID-19) remains unclear.

Purpose of the Study:

  • To investigate Nox2 activation in patients hospitalized with COVID-19.
  • To determine the association between Nox2 activation, disease severity, and thrombotic events in COVID-19.

Main Methods:

  • Quantified soluble Nox2-derived peptide (sNox2-dp) levels in COVID-19 patients (n=182) and controls (n=91).
  • Compared sNox2-dp levels based on disease severity and presence of thrombotic events.
  • Utilized logistic regression to identify predictors of thrombotic events.

Main Results:

  • sNox2-dp levels were significantly higher in COVID-19 patients compared to controls.
  • Elevated sNox2-dp levels correlated with severe COVID-19 and the occurrence of thrombotic events.
  • Logistic regression identified sNox2 and coronary heart disease as predictors of thrombotic events.

Conclusions:

  • Nox2 activation, indicated by elevated sNox2-dp, is associated with increased oxidative stress in COVID-19.
  • Nox2 activation is linked to severe COVID-19 disease progression.
  • Nox2 activation is a significant factor in the development of thrombotic events among COVID-19 patients.