Related Experiment Video

Updated: Dec 13, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

4.0K

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer

Maria Beecher1, Namrata Kumar2, Sunbok Jang3

  • 1Molecular Pharmacology Graduate Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.

DNA Repair
|August 3, 2020
PubMed

Insights

UV-damaged DNA binding protein (UV-DDB) is crucial for DNA repair. This review covers its structure, function, and potential roles in cancer and base excision repair.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • UV-damaged DNA binding protein (UV-DDB) is a heterodimer of DDB1 and DDB2.
  • UV-DDB plays a key role in global genome nucleotide excision repair.
  • Mutations in DDB2 are linked to xeroderma pigmentosum complementation group E.

Purpose of the Study:

  • To provide a historical perspective on UV-DDB.
  • To review the current knowledge of UV-DDB's structure and function.
  • To discuss emerging data on UV-DDB's non-canonical roles.

Main Methods:

  • Literature review of UV-DDB research.
  • Analysis of UV-DDB's role in DNA repair pathways.
  • Discussion of emerging findings on UV-DDB functions.

Main Results:

  • UV-DDB facilitates DNA repair by relaxing chromatin via histone ubiquitination.
  • UV-DDB is involved in repairing UV-induced DNA photoproducts.
  • Emerging evidence suggests non-canonical roles in base excision repair.

Conclusions:

  • UV-DDB is a critical DNA repair protein with established roles in nucleotide excision repair.
  • Further research into UV-DDB's non-canonical functions may reveal its involvement in cancer etiology.
  • Understanding UV-DDB's multifaceted roles is essential for comprehending DNA repair and disease.
Keywords:
Nucleotide excision repairSingle moleculeStructure-functionUV-DDBXP-EXeroderma pigmentosum

More Related Videos

Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation12:29

Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation

Published on: March 20, 2018

9.8K
Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging06:44

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

4.4K

Related Concept Videos

Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
42.4K
Mutations01:39

Mutations

Overview
93.7K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
4.7K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
40.3K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.1K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

4.1K