Dynamics of a cell motility model near the sharp interface limit
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Updated: Dec 13, 2025

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
Published on: May 22, 2021
Nicolas Bolle1, Matthew S Mizuhara1
1Department of Mathematics and Statistics, The College of New Jersey Ewing Township, NJ, United States.
Abstract:
Phase-field models have recently had great success in describing the dynamic morphologies and motility of eukaryotic cells. In this work we investigate the minimal phase-field model introduced in Berlyand et al. (2017). Rigorous analysis of its sharp interface limit dynamics was completed in Mizuhara et al. (2016) and Mizuhara et al. (2019), where it was observed that persistent cell motion was not stable. In this work we numerically study the pre-limiting phase-field model near the sharp interface limit, to better understand this lack of persistent motion. We find that immobile, persistent, and rotating states are all exhibited in this minimal model, and investigate the loss of persistent motion in the sharp interface limit.
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