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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Modern Treatments and Future Directions for Relapsed/Refractory Multiple Myeloma Patients

Vikram Premkumar1, Divaya Bhutani1, Suzanne Lentzsch1

  • 1Division of Hematology/Oncology, Columbia University Medical Center, New York, NY.

Clinical Lymphoma, Myeloma & Leukemia
|August 3, 2020
PubMed

Insights

Treatment advances have improved survival for multiple myeloma patients, but the disease remains incurable. This review covers current strategies for managing relapsed or refractory multiple myeloma.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Pharmacy

Background:

  • Multiple myeloma patient longevity has significantly increased due to novel therapies.
  • Despite improved prognoses, multiple myeloma is incurable, leading to frequent relapses.
  • The dynamic treatment landscape necessitates careful consideration of treatment sequencing.

Purpose of the Study:

  • To review current data and treatment approaches for relapsed/refractory multiple myeloma.
  • To provide insights into managing complex treatment sequences in multiple myeloma.

Main Methods:

  • Literature review of recent studies and prospective trials.
  • Analysis of current therapeutic options for relapsed/refractory multiple myeloma.

Main Results:

  • Proteasome inhibitors, immunomodulators, and monoclonal antibodies have improved outcomes.
  • Treatment sequencing remains a complex challenge in managing relapsed disease.

Conclusions:

  • Ongoing research continues to evolve multiple myeloma treatment paradigms.
  • Effective management of relapsed/refractory multiple myeloma requires a strategic approach to therapy sequencing.
Keywords:
Antibody therapyImmunotherapyMonoclonal gammopathiesMyelomaPlasma cell dyscrasias

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