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Reducing hyperpigmentation after sclerotherapy: A randomized clinical trial.

Alejandro Jose Gonzalez Ochoa¹, Joaquín Carrillo², Diana Manríquez²

¹HGZ 12 Instituto Mexicano del Seguro Social, San Luis Rio Colorado, Sonora, Mexico; CLINEDEM, San Luis Rio Colorado, Sonora, Mexico.

Journal of Vascular Surgery. Venous and Lymphatic Disorders

|August 3, 2020

Summary

This summary is machine-generated.

Adding sulodexide to sclerotherapy significantly reduced hyperpigmentation after varicose vein treatment. This venoactive drug improves outcomes without compromising vein elimination efficacy.

Keywords:

Hyperpigmentation Polidocanol Sclerotherapy Sulodexide

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Area of Science:

Vascular Medicine
Dermatology
Pharmacology

Background:

Sclerotherapy is a common treatment for varicose veins.
Post-sclerotherapy hyperpigmentation is a frequent adverse event.
Venoactive drugs are being investigated for their potential benefits.

Purpose of the Study:

To evaluate if adding sulodexide to sclerotherapy reduces hyperpigmentation.
To assess the impact on vein elimination and other adverse events.

Main Methods:

A prospective, multicenter, randomized controlled trial was conducted.
720 patients with varicose veins were included.
Group A received sulodexide plus sclerotherapy; Group B received standard sclerotherapy.

Main Results:

After 1 month, hyperpigmentation incidence was lower in the sulodexide group (8.7% vs. 14.8%).
The average area of hyperpigmentation was also reduced with sulodexide (10.7% vs. 18.2%).
Vein disappearance rates were similar between groups.

Conclusions:

Adding sulodexide to sclerotherapy effectively reduces post-treatment hyperpigmentation.
This adjunct therapy does not negatively impact the therapeutic efficacy of sclerotherapy for varicose veins.