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Related Experiment Video

Updated: Dec 13, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Castleman disease. Interaction with dermatopathy: Case report.

M L A Modolin1, C P Camargo2, D A Milcheski1

  • 1Universidade de São Paulo - Hospital das Clínicas, School of Medicine Universidade de São Paulo, Brazil.

International Journal of Surgery Case Reports
|August 3, 2020
PubMed
Summary

Castleman disease (CD) is a lymphoproliferative disorder. This case report details a unicentric CD in the inguinal region associated with skin lesions, suggesting erysipelas may have triggered lymph node hypertrophy.

Keywords:
Castleman diseaseLymphedemaSkin woundWound

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Castleman disease (CD) is a rare lymphoproliferative disorder characterized by lymph node hypertrophy.
  • Unicentric CD (UCD) affects a single lymph node or chain, while multicentric CD (MCD) involves multiple chains, potentially causing compressive symptoms.
  • This report focuses on a UCD case presenting unusually in the inguinal region alongside extensive skin lesions.

Observation:

  • A 43-year-old female presented with recurrent erysipelas on her left leg and a concurrent inguinal tumor mass.
  • Biopsy confirmed Castleman disease, specifically the unicentric form.
  • Surgical resection of affected skin and lymph node excision were performed due to the patient's poor skin condition.

Findings:

  • The study presents a rare case of unicentric Castleman disease in the inguinal region.
  • The co-occurrence of erysipelas and lymph node hypertrophy suggests a potential link between skin inflammation and CD development.
  • Surgical intervention led to clinical improvement.

Implications:

  • Erysipelas may act as a trigger for lymphangitis, lymphedema, and subsequent lymph node hypertrophy in susceptible individuals.
  • Further research into inflammatory responses and markers like interleukin-6 is crucial for understanding CD pathogenesis.
  • Integrating dermatological assessment is important for diagnosing and managing CD, especially when skin manifestations are present.