Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

UCL Queen Square Institute of Neurology: 75 years of innovation.

The Lancet. Neurology·2026

Same author

Causal information changes how we reason: a mixed-methods analysis of decision-making with causal information.

Frontiers in cognition·2026

Same author

Reducing Motion Artifact in High Resolution 7 T MRI Using the Magnetic Resonance Minimal Motion ("MR-MinMo") Head Stabilization Device.

Magnetic resonance in medicine·2026

Same author

Multivariate age-related variations in quantitative MRI maps: widespread age-related differences revisited.

Frontiers in neuroscience·2026

Same author

Characterization and Validation of Compressed Sensing for Time-of-Flight MRI Angiography of the Human Brain at 3T and 7T.

bioRxiv : the preprint server for biology·2026

Same author

Pupil dilation as a marker of attention/effort in aging and mild cognitive impairment.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same journal

Lifespan Trajectories of the Brain's Functional Complexity Characterized by Multiscale Sample Entropy.

NeuroImage·2026

Same journal

Pleasant fragrance modulates dyadic social sharing of positive emotion: Sharer-centered socioemotional enhancement effect and its neural couplings.

NeuroImage·2026

Same journal

Altered Functional Hierarchical and Sequential Organization in Individuals with Schizophrenia during Auditory Processing.

NeuroImage·2026

Same journal

Mechanical Deformation Explains Distinct Neuroimaging Patterns and Etiologies in Brain Trauma.

NeuroImage·2026

Same journal

Ventral striatum temporal interference brain stimulation enhances the reward-positivity event-related potential and reduces anxiety.

NeuroImage·2026

Same journal

NeuroHarm‑Kit: An Open‑Source Toolbox for Benchmarking Deep‑Learning Harmonization of Multi‑Site T1‑Weighted MRI.

NeuroImage·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 13, 2025

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

Published on: November 10, 2015

Does hippocampal volume explain performance differences on hippocampal-dependant tasks?

Ian A Clark¹, Anna M Monk¹, Victoria Hotchin¹

¹Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, UK.

|August 3, 2020

Summary

This summary is machine-generated.

Hippocampal grey matter volume does not significantly impact cognitive functions like memory and navigation in healthy adults. This study found no link between brain structure and performance on tasks requiring the hippocampus.

Keywords:

Autobiographical memory Future thinking Hippocampal volume Individual differences Scene construction Spatial navigation

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Related Experiment Videos

Last Updated: Dec 13, 2025

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

Published on: November 10, 2015

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Area of Science:

Neuroscience
Cognitive Psychology
Neuroimaging

Background:

Individual differences in cognitive abilities like scene imagination, memory recall, future thinking, and navigation are well-documented.
The hippocampus is crucial for these functions, leading to hypotheses about its grey matter volume influencing performance variability.

Purpose of the Study:

To investigate the relationship between hippocampal grey matter volume and performance on key cognitive tasks in a large sample of healthy young adults.
To address limitations of previous studies by using advanced neuroimaging and robust statistical methods.

Main Methods:

Structural magnetic resonance imaging (MRI) was used to collect whole-brain data from 217 healthy young adults.
Participants completed tasks assessing scene imagination, autobiographical memory, future thinking, and navigation.
Voxel-based morphometry and partial correlations were employed, analyzing whole-brain and hippocampal regions of interest.

Main Results:

No significant relationship was found between hippocampal grey matter volume and performance across the cognitive tasks.
This finding held true across different analytical approaches, subgroup analyses (gender, performance level), and when using latent cognitive variables.

Conclusions:

Hippocampal grey matter volume does not appear to be a major determinant of cognitive task performance in the general healthy population.
Significant volume differences related to ability are more likely observed in specialized populations, such as London taxi drivers.