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Advances in immunotherapy for cervical cancer
R Wendel Naumann1, Charles A Leath2
1Levine Cancer Institute, Atrium Health, Charlotte, North Carolina.
Current Opinion in Oncology
|August 3, 2020
Summary
Novel immunotherapies show promise for recurrent cervical cancer, offering durable responses. Research is ongoing to optimize combinations with checkpoint inhibitors for improved patient outcomes.
Area of Science:
- Oncology
- Immunology
- Virology
Background:
- Recurrent cervical cancer lacks effective treatments, with limited second-line chemotherapy options.
- Current chemotherapy offers a 48% response rate and 17-month survival, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review the role of immunotherapy in treating recurrent cervical cancer.
- To highlight novel therapeutic approaches targeting viral antigens and immune responses.
Main Methods:
- Review of current clinical trials involving immunotherapy for cervical cancer.
- Analysis of programmed cell death 1 (PD-1) and anticytotoxic T-lymphocyte-associated protein 4 (CTLA4) inhibitors.
- Examination of combination therapies including checkpoint inhibitors, chemotherapy, and radiation.
Main Results:
- Immunotherapy demonstrates broad activity and can induce dramatic, durable responses in cervical cancer.
- Pembrolizumab is approved for PD-L1 positive recurrent cervical cancer based on KEYNOTE-158 trial results.
- Combinations of PD-1 and CTLA4 inhibitors show promising durable activity.
Conclusions:
- Immunotherapy offers a potent strategy for recurrent cervical cancer.
- Ongoing research focuses on optimizing immunotherapy combinations and treatment settings.
- Further investigation is needed to maximize the potential of immune-based therapies.
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