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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Related Experiment Video

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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
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Necrotizing vasculitis and atherosclerosis.

V A Alegre1, R K Winkelmann

  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.

The British Journal of Dermatology
|September 1, 1988
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Summary
This summary is machine-generated.

Severe atherosclerosis and necrotizing vasculitis can coexist in older adults, leading to severe skin lesions and amputations. This combination appears to worsen the clinical and pathological presentation of both conditions.

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Area of Science:

  • Vascular Medicine
  • Dermatology
  • Pathology

Background:

  • Atherosclerosis is a common condition affecting large and medium vessels.
  • Necrotizing vasculitis involves inflammation and damage to blood vessels.
  • The interplay between these two conditions is not well understood.

Purpose of the Study:

  • To describe cases of patients with both severe atherosclerosis and necrotizing vasculitis.
  • To analyze the clinical and pathological manifestations of this combined condition.

Main Methods:

  • Case series describing five patients aged 50 years and above.
  • Clinical and pathological data review.

Main Results:

  • All patients had severe atherosclerosis and necrotizing vasculitis.
  • Vasculitis affected small vessels in four patients and medium vessels in one.
  • All patients presented with necrotic ulcerative skin lesions; two required amputation.

Conclusions:

  • Co-occurrence of severe atherosclerosis and necrotizing vasculitis can exacerbate disease expression.
  • This combination presents with severe skin manifestations and may necessitate amputation.