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Nociceptive related microRNAs and their role in rheumatoid arthritis

S Reyes-Long1,2, J L Cortes-Altamirano1, D Clavijio-Cornejo3

  • 1Department of Neurosciences, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Calzada México-Xochimilco 289, Col. Arenal de Guadalupe, Del. Tlalpan, 14389, Mexico City, Mexico.

Molecular Biology Reports
|August 3, 2020
PubMed

Insights

MicroRNAs (miRNAs) are implicated in rheumatoid arthritis (RA) pathogenesis. Six specific miRNAs are dysregulated in RA patients, influencing pain and autoimmune responses through gene repression.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Rheumatoid Arthritis (RA) is a prevalent autoimmune disease affecting approximately 1% of the global population.
  • Pain is a primary early symptom of RA, significantly impacting patient quality of life.
  • MicroRNAs (miRNAs) are small non-coding RNAs crucial for regulating cellular functions and are implicated in various diseases.

Purpose of the Study:

  • To investigate the role of miRNAs in the pathogenesis of Rheumatoid Arthritis (RA).
  • To identify specific miRNAs involved in pain modulation and autoimmune responses in RA patients.

Main Methods:

  • Conducted comprehensive literature searches in scientific databases using keywords related to "micro-RNA", "rheumatoid arthritis", "pain", and "nociception".
  • Reviewed studies focusing on the expression and function of miRNAs in the context of RA and pain pathways.

Main Results:

  • Identified six specific miRNAs (miR-16-5p, miR-23b-3b, miR-124-3p, miR-146a-5p, miR-155-5p, miR-223-3p) that are dysregulated in RA patients.
  • These miRNAs modulate key molecular pathways including NF-κB, TNF-α, interleukins, and TLR4, which are central to nociception, inflammation, and autoimmune responses.
  • Demonstrated that these miRNAs regulate nociceptive processes and autoimmune responses in RA through gene repression.

Conclusions:

  • Specific miRNAs play a significant role in the pathogenesis of RA by influencing both pain signaling and autoimmune mechanisms.
  • Dysregulation of miRNAs like miR-16-5p, miR-23b-3b, miR-124-3p, miR-146a-5p, miR-155-5p, and miR-223-3p contributes to RA symptoms and progression.
  • These miRNAs represent potential therapeutic targets and biomarkers for Rheumatoid Arthritis.
Keywords:
Micro-RNANociceptionPainRheumatoid arthritismiRNA

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