Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

659
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
659

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebrospinal fluid markers of central nervous system injury in decompression illness - a case-controlled pilot study.

Diving and hyperbaric medicine·2015
Same author

Total-tau and neurofilament light in CSF reflect spinal cord ischaemia after endovascular aortic repair.

Neurochemistry international·2015
Same author

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Neurobiology of aging·2015
Same author

Neuromodulation of fast-spiking and non-fast-spiking hippocampal CA1 interneurons by human cerebrospinal fluid.

The Journal of physiology·2015
Same author

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay.

Molecular neurodegeneration·2015
Same author

Apolipoprotein E ϵ4 is positively related to spatial performance but unrelated to hippocampal volume in healthy young adults.

Behavioural brain research·2015

Related Experiment Video

Updated: Dec 13, 2025

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data
06:14

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data

Published on: April 18, 2019

6.7K

Fluid Biomarkers for Chronic Traumatic Encephalopathy.

Pashtun Shahim1, Jessica M Gill2, Kaj Blennow1,3

  • 1Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

Seminars in Neurology
|August 3, 2020
PubMed
Summary

Diagnosing chronic traumatic encephalopathy (CTE) is challenging due to nonspecific symptoms. This review explores fluid biomarkers for repetitive head trauma and CTE, aiming for improved diagnosis and treatment.

More Related Videos

A Repetitive Concussive Head Injury Model in Mice
05:42

A Repetitive Concussive Head Injury Model in Mice

Published on: October 12, 2016

12.3K
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.5K

Related Experiment Videos

Last Updated: Dec 13, 2025

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data
06:14

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data

Published on: April 18, 2019

6.7K
A Repetitive Concussive Head Injury Model in Mice
05:42

A Repetitive Concussive Head Injury Model in Mice

Published on: October 12, 2016

12.3K
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.5K

Area of Science:

  • Neurology
  • Neuroscience
  • Sports Medicine

Background:

  • Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease linked to repetitive head impacts.
  • Current diagnostic methods for CTE rely on post-mortem examination, lacking in-vivo biomarkers.
  • Clinical symptoms of CTE, such as behavioral, cognitive, and mood changes, are nonspecific and appear after a latency period.

Purpose of the Study:

  • To review existing literature on fluid biomarkers for repetitive head trauma, post-concussive syndrome, and CTE.
  • To identify potential candidate biomarkers for CTE diagnosis during life.
  • To discuss challenges and future directions for advancing fluid biomarkers into clinical practice.

Main Methods:

  • Literature review of studies on fluid biomarkers related to head trauma and CTE.
  • Analysis of current diagnostic limitations for CTE.
  • Exploration of potential fluid biomarker candidates and their technical challenges.

Main Results:

  • No definitive fluid or imaging biomarker currently exists for diagnosing CTE during life.
  • Symptoms of CTE are nonspecific, complicating differential diagnosis.
  • Research is ongoing to identify and validate objective biomarkers for CTE pathophysiology.

Conclusions:

  • Objective fluid biomarkers are crucial for understanding CTE progression and developing interventions.
  • Further research and technical advancements are needed to translate promising biomarker candidates into routine clinical use.
  • Identifying reliable biomarkers will aid in early diagnosis, prevention, and treatment strategies for CTE.