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This study shows a digital health intervention effectively improved attention and real-world function in patients with hemispatial neglect. The treatment offers a scalable, self-administered option for care.

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Area of Science:

  • Neuroscience
  • Digital Health
  • Rehabilitation Medicine

Background:

  • Hemispatial neglect is a common, debilitating attention deficit following acquired brain injury.
  • Current treatments for hemispatial neglect have limitations in accessibility and scalability.
  • Digital interventions offer a promising avenue for improving attention regulation.

Purpose of the Study:

  • To evaluate the effectiveness of a digital health intervention for chronic hemispatial neglect.
  • To target the intrinsic regulation of goal-directed alertness in patients with hemispatial neglect.
  • To assess improvements in attention, functional abilities, and other cognitive domains.

Main Methods:

  • A multisite, randomized, double-blinded, controlled trial was conducted.
  • Forty-nine participants with hemispatial neglect were randomized to an attention remediation treatment or an active control group.
  • Interventions were remotely administered for 12 weeks, with assessments before, immediately after, and 3 months post-intervention.

Main Results:

  • The intervention group showed a significant reduction in spatial bias on the Posner cueing task (p=0.010, Cohen's d=0.96).
  • Significant improvements were observed in functional abilities, including the Catherine Bergego and Barthel indices (p=0.027, Cohen's d=0.24).
  • Benefits generalized to real-world functional improvements.

Conclusions:

  • The digital attention training program effectively improved attention deficits in hemispatial neglect.
  • The intervention demonstrated a positive impact on functional abilities, suggesting generalization of effects.
  • This safe, scalable, and self-administered treatment may complement existing standards of care for hemispatial neglect.