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Trends of Antifungal Use Based on Sales Data in Japan from 2006 to 2015

Ayako Kawabe1, Yuichi Muraki1, Ryo Inose1

  • 1Department of Clinical PharmacoEpidemiology, Kyoto Pharmaceutical University.

Biological & Pharmaceutical Bulletin
|August 4, 2020
PubMed

Insights

Antifungal use in Japan decreased overall from 2006-2015, with significant declines in treatments for superficial mycoses. However, invasive fungal infection treatment use increased, possibly due to more immunocompromised patients.

Area of Science:

  • Medical Mycology
  • Epidemiology
  • Pharmacoeconomics

Background:

  • The epidemiology of fungal infections in Japan remains unclear.
  • Treatment options for fungal infections have expanded with new antifungals and guidelines.
  • Antifungal sales data can indicate trends in fungal infection prevalence.

Purpose of the Study:

  • To analyze trends in antifungal drug usage in Japan between 2006 and 2015.
  • To use sales data as a proxy for tracking fungal infection trends.
  • To identify shifts in the treatment of superficial versus invasive mycoses.

Main Methods:

  • Analysis of national antifungal drug sales data from 2006 to 2015.
  • Statistical evaluation of trends in overall, oral, and parenteral antifungal use.
  • Assessment of trends specifically for superficial and invasive mycoses treatments.

Main Results:

  • Total antifungal use in Japan significantly decreased during the study period.
  • Both oral and parenteral antifungal use showed significant declines.
  • Antifungal use for superficial mycoses decreased substantially, while use for invasive mycoses significantly increased.
  • The rise in invasive mycoses treatment correlates with an increasing immunocompromised population.

Conclusions:

  • Antifungal consumption patterns in Japan reveal a decrease in superficial mycoses treatment and an increase in invasive mycoses treatment.
  • The rise in invasive mycoses treatment is potentially linked to a growing number of immunocompromised individuals.
  • This study provides the first comprehensive analysis of antifungal use trends in Japan, highlighting the need for ongoing surveillance systems.
Keywords:
antifungal useinvasive mycosissuperficial mycosissurveillance

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