New-Onset Seizure as the Only Presentation in a Child With COVID-19

Sabita Bhatta1, Abida Sayed2, Bandana Ranabhat3

  • 1Pediatrics, Woodhull Medical Center, New York, USA.

Cureus
|August 4, 2020
PubMed

Insights

A child experienced a new-onset seizure without fever during the COVID-19 pandemic. This case highlights atypical neurological presentations of coronavirus disease 2019 (COVID-19).

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • The coronavirus disease 2019 (COVID-19) pandemic has seen a wide range of clinical presentations.
  • Neurological manifestations of COVID-19 are increasingly reported, but often associated with fever or respiratory symptoms.

Observation:

  • An 11-year-old male presented with a new-onset afebrile seizure during the COVID-19 crisis.
  • Initial examination and standard laboratory tests were unremarkable.
  • Chest X-ray and CT scan showed normal findings.

Findings:

  • The patient tested positive for SARS-CoV-2 via PCR.
  • The seizure was isolated, with no preceding fever or other COVID-19 symptoms.
  • The patient improved with anti-seizure medication.

Implications:

  • This case underscores the importance of considering COVID-19 in patients presenting with atypical neurological symptoms, even without typical signs of infection.
  • Recognizing unusual presentations of COVID-19 is crucial for timely diagnosis and management, especially during widespread outbreaks.
  • Pediatric neurology consultation is vital for managing such complex cases.

Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.2K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.0K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.1K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
768
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
499
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.4K