Related Experiment Video
Updated: Dec 13, 2025
Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
Published on: November 3, 2023
Pediatric Case of Severe COVID-19 With Shock and Multisystem Inflammation
David C Nguyen1, Hanan Haydar1, Elizabeth R Pace2
1Pediatric Infectious Diseases, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, USA.
Insights
Multisystem inflammatory syndrome in children (MIS-C) can occur after COVID-19 infection. SARS-CoV-2 IgG antibody testing aids diagnosis when RT-PCR is negative, suggesting MIS-C is immune-mediated.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Coronavirus disease 2019 (COVID-19) has emerged globally.
- While most pediatric COVID-19 cases are mild, a severe complication, multisystem inflammatory syndrome in children (MIS-C), has been identified.
- MIS-C presents with multi-organ system inflammation.
Abstract:
While the majority of pediatric coronavirus disease 2019 (COVID-19) cases have not been critical, occurrences of a multisystem inflammatory syndrome in children (MIS-C) have been emerging as the pandemic progresses. Herein, we report our experience with a pediatric COVID-19 case that presented with shock and multisystem inflammation. Our patient notably had multiple negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) assays but tested positive for SARS-CoV-2 IgG antibody. This case not only highlights the utility of SARS-CoV-2 IgG in the diagnosis of COVID-19 when RT-PCR is negative but suggests MIS-C may be a post-infectious immune-mediated process.
Related Concept Videos
01:30Pneumonia III: Complications and Assessment
01:29Pneumonia II: Pathophysiology
01:21Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:30Acute Respiratory Failure-III
01:21Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
01:24Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...