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Updated: Dec 13, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Sulfenylation of Arenes with Ethyl Arylsulfinates in Water
Yueting Wei1, Jing He1, Yali Liu1
1School of Chemistry and Chemical Engineering, The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi City 832004, China.
Abstract:
A tetrabutylammonium iodide-mediated direct sulfenylation of arenes with ethyl arylsulfinates in water was developed. Various electron-rich arenes and ethyl arylsulfinates were investigated in the reaction, and a series of aryl sulfides were obtained in excellent yields. The advantages of this green protocol were simple reaction conditions (metal-free, water as the solvent, and under air), odorless and easily available sulfur reagent, broad substrate scope, and gram-scale synthesis. Moreover, the potential application of aryl sulfides was exemplified by further transformations.
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