Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Flora of the Large Intestine

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Drugs Affecting GI Tract Motility: Other Laxatives

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular Detection and Identification of Bacterial Pathogens in Qinghai Province, China.

Pathogens (Basel, Switzerland)·2026

Same author

Discovery of key surface electromyography features during walking for discerning high and low muscle mass using machine learning analysis.

Scientific reports·2026

Same author

Obesity indicators and risk of mortality and functional health outcomes in Asian community-dwelling older adults: A systematic review and meta-analysis.

Experimental gerontology·2025

Same author

Interpretable Machine Learning for the Design of (K, Na)NbO<sub>3</sub>-Based Piezoceramics Using Combinatorial and Knowledge-Embedded Descriptors.

ACS applied materials & interfaces·2025

Same author

Chronic low water intake is associated with altered exercise-induced oxidative stress and immune cell responses: a cross-sectional study.

Journal of the International Society of Sports Nutrition·2025

Same author

Development and validation of machine learning models for classifying cancer-related sarcopenia using Kinect-based mixed-reality exercises in breast cancer survivors.

Translational cancer research·2025

Search research articles

Related Experiment Video

Updated: Dec 13, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Exercise, the Gut Microbiome, and Frailty.

Hyung Eun Shin¹, Seong Eun Kwak¹, Ji-Hyun Lee¹

¹Health and Exercise Science Laboratory, Seoul National University, Seoul, Korea.

Annals of Geriatric Medicine and Research

|August 4, 2020

Summary

Exercise may promote healthy aging by positively impacting the gut microbiome, potentially preventing age-related physical frailty and cognitive dysfunction. Further research is needed to clarify the exact mechanisms involved.

Keywords:

Cognitive dysfunction Exercise Frailty Gastrointestinal microbiome Short chain fatty acids

More Related Videos

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

Related Experiment Videos

Last Updated: Dec 13, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

Area of Science:

Gerontology
Microbiology
Exercise Science

Background:

The gut microbiome plays a crucial role in skeletal muscle and brain function.
Gut microbiome dysbiosis is linked to accelerated aging and age-related diseases like physical frailty and cognitive dysfunction.

Purpose of the Study:

To review the current understanding of the gut microbiome's role in aging, focusing on physical frailty and cognitive dysfunction.
To investigate the impact of exercise training on the gut microbiome and its potential to promote healthy aging.

Main Methods:

A comprehensive literature review was conducted using major scientific databases (PubMed, Google Scholar, SCOPUS, etc.).
Search terms included 'gut microbiome', 'exercise', 'physical frailty', and 'cognitive dysfunction'.

Main Results:

A strong correlation exists between the gut microbiome and both cognitive dysfunction and physical frailty.
Exercise training significantly influences the composition of the gut microbiome.

Conclusions:

Exercise training may prevent physical frailty and cognitive dysfunction by modulating the gut microbiome.
The precise mechanisms underlying these effects require further investigation.
Future studies should focus on elucidating how exercise-induced gut microbiome changes contribute to healthy aging.