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Diabetic Peripheral Neuropathy as a Risk Factor for Sarcopenia
Tae Jung Oh1,2, Yoojung Song2, Jae Hoon Moon1,2
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Annals of Geriatric Medicine and Research
|August 4, 2020
Summary
Diabetic peripheral neuropathy (DPN) is common in type 2 diabetes. Sarcopenia, characterized by muscle dysfunction, was linked to higher neuropathy questionnaire scores in patients with DPN.
Area of Science:
- Endocrinology
- Geriatrics
- Neurology
Background:
- Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes, increasing with age.
- DPN is associated with muscle dysfunction, but its link to sarcopenia requires further investigation.
Purpose of the Study:
- To investigate the association between DPN and sarcopenia in patients with type 2 diabetes.
- To determine if neuropathy severity correlates with sarcopenia indicators.
Main Methods:
- 170 type 2 diabetes patients underwent assessments for hand grip strength, lean body mass, and gait speed.
- Sarcopenia was diagnosed using Asian Working Group for Sarcopenia criteria.
- Neuropathy was evaluated using small- and large-fiber examinations and the Michigan Neuropathy Screening Instrument Questionnaire (MNSI-Q).
Main Results:
- 24% of participants were diagnosed with sarcopenia.
- Sarcopenia patients exhibited higher MNSI-Q scores (p=0.008).
- MNSI-Q scores were negatively associated with hand grip strength and predicted sarcopenia presence (adjusted OR=1.310).
Conclusions:
- Sarcopenia in type 2 diabetes patients correlates with increased neuropathy questionnaire scores.
- Active screening for sarcopenia is recommended in individuals with DPN.
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