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Motoric Cognitive Risk Syndrome: A Risk Factor for Cognitive Impairment and Dementia in Different Populations

Zeev Meiner1, Emmeline Ayers2, Joe Verghese2,3

  • 1Department of Physical Medicine and Rehabilitation, Hadassah Mount Scopus, Jerusalem, Israel.

Annals of Geriatric Medicine and Research
|August 4, 2020
PubMed

Insights

Motoric cognitive risk syndrome (MCR), characterized by slow gait and cognitive complaints, identifies older adults at high risk for dementia. Understanding MCR mechanisms can help reduce dementia and disability burdens.

Area of Science:

  • Gerontology
  • Neurology
  • Public Health

Background:

  • Gait changes, particularly slowed velocity, can signal cognitive decline in aging populations.
  • Motoric cognitive risk syndrome (MCR) is a pre-dementia syndrome combining slow gait and cognitive complaints, identifying individuals at high risk for dementia.
  • MCR affects approximately 10% of older adults globally and is linked to adverse outcomes like falls, disability, frailty, and mortality.

Purpose of the Study:

  • To highlight the significance of Motoric Cognitive Risk Syndrome (MCR) as a pre-dementia syndrome.
  • To discuss the prevalence, risk factors, and adverse outcomes associated with MCR.
  • To emphasize the clinical utility and advantages of MCR over other pre-dementia syndromes.

Main Methods:

  • Literature review and synthesis of existing research on Motoric Cognitive Risk Syndrome (MCR).
  • Analysis of MCR prevalence data, including a Korean cohort.
  • Identification and summary of reported risk factors and associated adverse conditions.

Main Results:

  • Motoric Cognitive Risk Syndrome (MCR) has a global prevalence of about 10%.
  • Risk factors for MCR include older age, low education, cardiovascular disease, obesity, physical inactivity, and depression.
  • MCR is a predictor of dementia, falls, disability, frailty, and mortality.

Conclusions:

  • Motoric Cognitive Risk Syndrome (MCR) is a valuable, simple-to-implement tool for identifying at-risk older adults.
  • Further research into MCR mechanisms is crucial for developing interventions to mitigate dementia and disability.
  • MCR offers advantages over other pre-dementia syndromes due to its simplicity and resource efficiency.
Keywords:
Cognitive impairmentDementiaGaitMotoric cognitive risk syndrome

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