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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Urinary biomarkers in lupus nephritis
Cristian C Aragón1, Raúl-Alejandro Tafúr1,2, Ana Suárez-Avellaneda1
1GIRAT: Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Fundación Valle Del Lili and Universidad Icesi, Cali, Colombia.
Journal of Translational Autoimmunity
|August 4, 2020
Summary
Urinary biomarkers show promise for monitoring lupus nephritis (LN), a kidney complication of systemic lupus erythematosus (SLE). These markers may help predict disease flares and treatment response, offering an alternative to invasive kidney biopsies.
Area of Science:
- Nephrology
- Immunology
- Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease.
- Lupus nephritis (LN), kidney inflammation in SLE patients, affects 30-70% of cases.
- Kidney biopsy is the standard for LN classification but has limitations in predicting treatment response and monitoring disease activity.
Purpose of the Study:
- To review advances in urinary biomarkers for lupus nephritis.
- To highlight the potential of these biomarkers in early detection of sub-clinical flares and monitoring therapeutic response.
- To discuss the role of certain biomarkers in the pathogenesis of LN.
Main Methods:
- Review of current literature on lupus nephritis urinary biomarkers.
- Analysis of conventional and non-conventional urinary markers.
- Correlation of biomarker findings with histological LN classifications.
Main Results:
- Various conventional biomarkers (e.g., proteinuria) and non-conventional biomarkers (e.g., MCP-1) are studied for LN.
- Urinary biomarkers offer a less invasive approach compared to serial kidney biopsies.
- Some biomarkers are implicated in the underlying mechanisms of lupus nephritis.
Conclusions:
- Urinary biomarkers are valuable tools for complementing traditional methods in LN management.
- Future research should focus on validating these markers for early flare prediction and therapy monitoring.
- Understanding biomarker involvement in LN pathogenesis may lead to targeted therapies.
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