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Related Experiment Video

Updated: Dec 13, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

A modular microarray imaging system for highly specific COVID-19 antibody testing.

Per Niklas Hedde^1,2,3, Timothy J Abram⁴, Aarti Jain⁵

¹Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA. phedde@uci.edu.

|August 4, 2020

Summary

This summary is machine-generated.

A new, affordable 3D-printable TinyArray imager rapidly detects SARS-CoV-2 antibodies from finger prick blood. This portable device enables widespread serosurveillance for COVID-19 containment and vaccine development.

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Last Updated: Dec 13, 2025

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Published on: April 6, 2021

Area of Science:

Biomedical Engineering
Infectious Disease Diagnostics
Medical Imaging

Background:

Accurate detection of SARS-CoV-2 antibodies is crucial for understanding COVID-19 spread.
Existing diagnostic tools can be expensive and require specialized infrastructure.
Large-scale serosurveillance is vital for public health strategies.

Purpose of the Study:

To develop a low-cost, portable imaging platform for detecting antibodies against SARS-CoV-2.
To create a rapid diagnostic tool for use in resource-limited settings.
To enable efficient serosurveillance for COVID-19.

Main Methods:

Development of a 3D-printable portable imaging platform (TinyArray imager).
Design of coronavirus antigen microarrays (CoVAMs) including SARS-CoV-2 antigens.
Testing the imager with COVID-19 positive and negative human sera.

Main Results:

The TinyArray imager demonstrated high sensitivity and specificity in detecting SARS-CoV-2 antibodies.
Performance was comparable to a commercial microarray reader costing 100 times more.
The device achieved a rapid test turnaround time of 2-4 hours.

Conclusions:

The TinyArray imager is a robust, inexpensive, and portable solution for antibody detection.
This technology facilitates rapid, large-scale serosurveillance in diverse settings.
The platform supports efforts in COVID-19 containment, therapeutics, and vaccine development.