Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

315
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
315
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

93
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
93
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

107
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
107
Shape and Texture of Coarse Aggregate01:25

Shape and Texture of Coarse Aggregate

478
Aggregate shape is classified based on the relative sharpness or roundness of the edges and corners. This classification includes categories like rounded, angular, elongated, and flaky, each with specific characteristics. Rounded aggregates, fully shaped by attrition, are typical of river or seashore gravel, while angular aggregates, such as crushed rock, have well-defined edges. Aggregates that are elongated and flaky are less desirable, as they can reduce the workability and strength of...
478
Compacting Factor test01:22

Compacting Factor test

438
The compacting factor test is a method used to assess the workability of concrete. It is  especially suitable for concrete mixes containing aggregates up to one and a half inches in size. This test involves specialized equipment consisting of two truncated cone-shaped hoppers and a cylinder, all with polished interior surfaces to minimize friction.
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
438
Factors Affecting Workability01:24

Factors Affecting Workability

224
The workability of concrete is a critical characteristic that influences the ease of mixing, handling, and finishing the concrete. It is affected by several factors including water content, aggregate properties, and admixtures like air entrainment. Water plays a fundamental role as it lubricates the concrete mix, facilitating easier movement and placement. However, the water requirement varies depending on the texture and shape of aggregates. Finer particles and angular, rough-textured...
224

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging clinical and educational contexts: mentalization-based techniques in educational settings.

Frontiers in psychology·2026
Same author

National Trends in Rectal Cancer Among Younger Patients: A National Cancer Database Analysis.

Cureus·2026
Same author

Masculine Norm Adherence Among Australian Men: Latent Structure of the CMNI-22 and Its Links With Mental Health Outcomes.

Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals·2026
Same author

A group motivational intervention to support motivation for physical activity among adults in residential treatment for substance use disorders: a series of N-of-1 studies.

Psychology & health·2026
Same author

Impact of physical activity on sleep in adults recovering from substance use disorders: a protocol for an N-of-1 observational study.

BMJ open·2025
Same author

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2025

Related Experiment Video

Updated: Dec 13, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
05:45

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

4.1K

Determining the Impact of Roller Compaction Processing Conditions on Granule and API Properties.

James Clarke1, John F Gamble2, John W Jones3

  • 1School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK.

AAPS Pharmscitech
|August 4, 2020
PubMed
Summary

Drug particle attrition during dry granulation impacts dosage form performance. This study found comminuted drug particles can remain free in roller compaction blends, aiding process optimization.

Keywords:
attritionmorphologically directed Raman spectroscopyparticle sizepharmaceuticalsroller compaction

More Related Videos

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

14.9K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.3K

Related Experiment Videos

Last Updated: Dec 13, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
05:45

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

4.1K
Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

14.9K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.3K

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Chemical Engineering

Background:

  • Drug particle attrition during dry granulation affects final dosage form performance.
  • The fate of comminuted particles within granules is not fully understood.
  • Understanding attrition and incorporation is key to optimizing granulation processes.

Purpose of the Study:

  • To investigate drug particle attrition during dry granulation.
  • To determine the incorporation of comminuted particles into granules using a Gerteis equipment train.
  • To enhance the understanding of granulation performance and process modeling.

Main Methods:

  • Examined attrition of Active Pharmaceutical Ingredient (API) particles.
  • Utilized a Gerteis roller compaction equipment train for dry granulation.
  • Analyzed post-milling blends to identify comminuted drug particles.

Main Results:

  • Confirmed that comminuted drug particles can exist freely in post-milling blends.
  • Demonstrated the presence of attrited API particles within the granulation mixture.
  • Provided insights into particle behavior during roller compaction.

Conclusions:

  • Comminuted drug particles are present in roller compaction blends.
  • This finding aids in understanding granulation performance.
  • Enables improved mechanistic models for process optimization.