Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Decoding the Complexity of Tricuspid Regurgitation Prognostic Drivers Using Explainable Artificial Intelligence.

European heart journal. Cardiovascular Imaging·2026

Same author

Improving structural heart disease screening: AI-ECG and novice AI-guided focused cardiac ultrasound.

NPJ digital medicine·2026

Same author

Smarter FoCUS: AI-guided focused cardiac ultrasound enables novice detection of left ventricular dysfunction.

European heart journal. Digital health·2026

Same author

Quantitative Analysis of the Impact of Region of Interest Information on Deep Learning Algorithms for Thyroid Ultrasound Imaging.

IEEE open journal of engineering in medicine and biology·2026

Same author

BRD2 upregulation as a pan-cancer adaptive resistance mechanism to BET inhibition.

Cellular & molecular biology letters·2026

Same author

Clinical Characteristics and Risk Factors for Syphilis Among People Living With Human Immunodeficiency Virus: A Nationwide Population-Based Cohort Study in Korea.

Journal of Korean medical science·2026

Search research articles

Related Experiment Video

Updated: Dec 13, 2025

Animal Model of Implant-Associated Infections in Mice

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

Antibacterial Nanopillar Array for an Implantable Intraocular Lens.

Goro Choi¹, Younseong Song¹, Hyungjun Lim²

¹Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.

Advanced Healthcare Materials

|August 4, 2020

Summary

This study developed an antibacterial nanopillar array for intraocular lenses (IOLs) to prevent infections after cataract surgery. The novel surface modification effectively eradicates bacteria, significantly reducing the risk of blindness.

Keywords:

antibacterial nanopillars initiated chemical vapor deposition intraocular lenses polymer nanopillar arrays surface modification

More Related Videos

Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

Published on: April 11, 2025

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Dec 13, 2025

Animal Model of Implant-Associated Infections in Mice

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

Published on: April 11, 2025

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Area of Science:

Biomaterials Science
Ophthalmology
Nanotechnology

Background:

Post-surgical intraocular lens (IOL) infections pose a significant risk of blindness.
Current treatments often require secondary surgeries to replace contaminated IOLs.
Preventing bacterial adhesion and proliferation on IOL surfaces is crucial for patient outcomes.

Purpose of the Study:

To develop a novel antibacterial surface modification for IOLs.
To create a nanopillar array (NPA) integrated onto IOLs capable of capturing and eradicating bacteria.
To evaluate the efficacy and safety of the modified IOL surface.

Main Methods:

Fabrication of a polymeric nanopillar array (NPA) on an IOL surface.
Application of an ionic antibacterial polymer layer using initiated chemical vapor deposition.
Modification of NPA dimensions and polymer coating for enhanced antibacterial activity and reduced cell adhesion.
Testing antibacterial efficiency against Staphylococcus aureus.

Main Results:

The developed ionic polymer-coated NPA demonstrated over 99% antibacterial efficiency against Staphylococcus aureus.
The NPA effectively captures and ruptures bacterial membranes through mechanical and chemical interactions.
The surface modification reduced corneal endothelial cell adhesivity and posterior capsule opacification without cytotoxicity.

Conclusions:

The novel ionic polymer-coated NPA offers an effective strategy to prevent bacterial contamination of IOLs.
This technology has the potential to significantly reduce postoperative complications like endophthalmitis after cataract surgery.
The approach combines topological and physicochemical surface modifications for enhanced antibacterial performance.