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The role of the stem cell epigenome in normal aging and rejuvenative therapy

Jeyan Jayarajan1,2, Michael D Milsom1,3,4

  • 1Division of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Human Molecular Genetics
|August 4, 2020
PubMed

Insights

Adult stem cells decline with age, impacting tissue repair. Epigenetic changes are key drivers, and resetting the epigenome may rejuvenate stem cell function.

Area of Science:

  • Gerontology
  • Stem Cell Biology
  • Epigenetics

Background:

  • Adult stem cells maintain tissue regeneration throughout life.
  • Functional decline of stem cells contributes to aging-related tissue deterioration.
  • Age-associated stem cell exhaustion is multifactorial.

Purpose of the Study:

  • To review mediators of epigenome remodeling during aging.
  • To discuss the impact of epigenetic changes on stem cell function.
  • To explore the potential of epigenome resetting for stem cell rejuvenation.

Main Methods:

  • Review of existing literature on stem cell aging and epigenetics.
  • Analysis of cell-intrinsic and extrinsic factors influencing epigenome remodeling.
  • Discussion of mechanisms linking epigenetic alterations to stem cell dysfunction.

Main Results:

  • Epigenome remodeling and gene expression deregulation are hallmarks of aging.
  • These epigenetic changes significantly impact aged stem cell function.
  • Cell-intrinsic and extrinsic factors contribute to age-related epigenome alterations.

Conclusions:

  • Epigenetic alterations are central to age-associated stem cell dysfunction.
  • Resetting the aged epigenome holds promise for rejuvenating stem cells.
  • Understanding these mechanisms is crucial for combating age-related decline.

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