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MiR-100 up-regulation enhanced cell autophagy and apoptosis induced by cisplatin in osteosarcoma by targeting mTOR

Z Yu1, N Li, K Jiang

  • 1Department of Medical Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

European Review for Medical and Pharmacological Sciences
|August 4, 2020
PubMed

Insights

This article has been withdrawn due to suspected research misconduct. The authors did not provide proof of data originality, leading to its retraction by the publisher.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Osteosarcoma is a primary bone cancer.
  • MicroRNAs (miRNAs) play roles in cancer development.
  • Cisplatin is a common chemotherapy drug.

Purpose of the Study:

  • To investigate the role of microRNA-100 (miR-100) in cisplatin-induced autophagy and apoptosis in osteosarcoma.
  • To explore the potential targeting of the mTOR pathway by miR-100.

Main Methods:

  • Cell culture models of osteosarcoma.
  • Transfection to up-regulate miR-100.
  • Assessment of cell autophagy and apoptosis.
  • Western blot analysis to examine mTOR pathway proteins.

Main Results:

  • Up-regulation of miR-100 enhanced cisplatin-induced autophagy and apoptosis in osteosarcoma cells.
  • miR-100 was found to target the mTOR pathway.

Conclusions:

  • miR-100 may serve as a therapeutic target to enhance cisplatin efficacy in osteosarcoma.
  • The findings suggest a mechanism involving miR-100, mTOR, autophagy, and apoptosis in osteosarcoma treatment.

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