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Targeting of GSK-3β by miR-214 to facilitate gastric cancer cell proliferation and decrease of cell apoptosis
1The 2nd Department of General Surgery, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, China.
Abstract:
Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Targeting of GSK-3β by miR-214 to facilitate gastric cancer cell proliferation and decrease of cell apoptosis, by H.-L. Li, S. Liang, J.-H. Cui, G.-Y. Han, published in Eur Rev Med Pharmacol Sci 2018; 22 (1): 127-134-DOI: 10.26355/eurrev_201801_14109-PMID: 29364479" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/14109.
Insights
This study on gastric cancer cell proliferation and apoptosis has been withdrawn due to suspected research misconduct. The authors did not provide evidence of data originality.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Gastric cancer is a significant global health concern.
- MicroRNAs (miRNAs) play crucial roles in cancer development and progression.
- Glycogen synthase kinase 3 beta (GSK-3β) is implicated in various cellular processes, including proliferation and apoptosis.
Purpose of the Study:
- To investigate the role of miR-214 in targeting GSK-3β.
- To understand the impact of this targeting on gastric cancer cell proliferation.
- To examine the effect on gastric cancer cell apoptosis.
Main Methods:
- In vitro studies involving gastric cancer cell lines.
- Analysis of miR-214 expression levels.
- Assessment of GSK-3β protein levels and activity.
- Cell proliferation assays.
- Cell apoptosis assays.
Main Results:
- The article reported that miR-214 targets GSK-3β.
- It suggested that this targeting facilitates gastric cancer cell proliferation.
- The study indicated a decrease in cell apoptosis.
Conclusions:
- The findings suggested a mechanism involving miR-214 and GSK-3β in gastric cancer.
- The study aimed to provide insights into potential therapeutic targets.
- However, the article has been withdrawn due to research misconduct concerns.
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