![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Stereoselective Remote Functionalization via Palladium-Catalyzed Redox-Relay Heck Methodologies.
Holly E Bonfield1,2, Damien Valette1, David M Lindsay2
1Chemical Development, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 4, 2020
Summary
This review summarizes palladium-catalyzed asymmetric redox-relay Heck-type reactions for efficiently creating chiral molecules. These methods are crucial for drug discovery, enabling the selective introduction of stereocenters in complex compounds.
Area of Science:
- Organic Chemistry
- Catalysis
- Medicinal Chemistry
Background:
- Drug discovery increasingly requires novel three-dimensional chemical structures.
- Efficient and stereoselective methods for introducing chirality are essential.
- Palladium-catalyzed reactions offer powerful tools for synthetic chemists.
Purpose of the Study:
- To review the development of palladium-catalyzed asymmetric redox-relay Heck-type processes.
- To showcase the scope and applications of these transformations.
- To discuss mechanistic aspects, limitations, and future directions.
Main Methods:
- Focus on palladium-catalyzed asymmetric redox-relay Heck-type reactions.
- Highlighting stereoselective synthesis of chiral molecules.
- Reviewing applications in drug discovery and synthesis of chiral building blocks.
Main Results:
- Demonstration of the broad scope of these Heck-type reactions.
- Successful application in synthesizing pharmaceutically relevant chiral compounds.
- Detailed mechanistic insights and identification of current limitations.
Conclusions:
- Palladium-catalyzed asymmetric redox-relay Heck-type processes are vital for stereoselective synthesis.
- These methods enable efficient access to complex chiral molecules for drug discovery.
- Further research is needed to overcome current limitations and expand applications.
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