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Updated: Dec 13, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
The Quinazoline-Chalcone and Quinazolinone-Chalcone Hybrids: A Promising Combination for Biological Activity
Eduardo Bustos Mass1, Gilmar Vieira Duarte1, Dennis Russowsky1
1Laboratorio de Sínteses Organicas, Instituto de Quimica, Universidade Federal do Rio Grande do Sul, Av. Bento Goncalves 9500, CEP 91501-970, Agronomia, Porto Alegre, RS, Brazil.
Abstract:
Quinazoline and/or chalcones derivatives are important targets in several areas of chemical sciences, mainly, in the medicinal chemistry and pharmaceutical research. The purpose of this review was to systematize the information available in the literature, including patents, regarding the benefits, exerted by the combination of these two pharmacophores into single molecules. These hybrid compounds can exhibit different biological activities, causing a synergistic or a new effect, compared to the individuals. The variability of biological activities includes anticancer, anti-Alzheimer, antiviral and antimicrobial activities, among others. Additionally, synthetic methodologies to prepare the different molecular architectures were discussed based on their similarities. The increasing number of publications indicates the importance of molecular hybridization in the field of drug discovery.
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