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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
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Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
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Improving IV Insulin Administration in a Community Hospital
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The Insulin Regimen That Works.

Svitlana Crawley1, Susan Chaney2

  • 1University of Colorado School of Medicine, Aurora, Colorado Svitlana.Crawley@ucdenver.edu.

Journal of Doctoral Nursing Practice
|August 4, 2020
PubMed
Summary
This summary is machine-generated.

Intensifying insulin therapy by adding rapid-acting insulin can improve glycemic control in type 2 diabetes patients. This approach helps achieve target HbA1c levels when basal insulin alone is insufficient.

Keywords:
basal insulin therapybasal-bolus insulin therapybasal-plus insulin therapyglycemic goalstype 2 diabetes mellitus

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Area of Science:

  • Endocrinology
  • Diabetes Management

Background:

  • Type 2 diabetes mellitus necessitates diligent glycemic control monitoring.
  • Treatment escalation is crucial if glucose levels exceed target goals despite adherence to current therapies.
  • When glycosylated hemoglobin (HbA1c) targets remain unmet with maximal basal insulin and fasting glucose is at goal, adding rapid-acting insulin is indicated.

Purpose of the Study:

  • To present an effective strategy for intensifying insulin therapy.
  • The method focuses on individual patient needs and self-management capabilities.

Main Methods:

  • A retrospective case review was conducted.
  • The case involved a patient referred to an Endocrinology Specialty Clinic for diabetes management.

Main Results:

  • Intensifying insulin therapy by incorporating once-daily rapid-acting insulin injections led to improved diabetes control.
  • The patient's overall diabetes management showed positive results after the treatment adjustment.

Conclusions:

  • Adding a single daily dose of rapid-acting insulin before meals can effectively lower HbA1c to below 7%.
  • This strategy is beneficial for patients on maximum basal insulin doses with controlled fasting glucose but elevated HbA1c.
  • Early intensification of antihyperglycemic therapy, aligned with ADA guidelines, is vital for reducing complication risks and achieving glycemic goals.