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Related Concept Videos

Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Related Experiment Video

Updated: Dec 13, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Imaging correlates of visual function in multiple sclerosis.

Eduardo Caverzasi1, Christian Cordano1, Alyssa H Zhu2

  • 1Division of Neuroimmunology and Glial Biology UCSF, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, United States of America.

Plos One
|August 4, 2020
PubMed
Summary
This summary is machine-generated.

Neuroimaging metrics like MRI and OCT can track visual impairment in multiple sclerosis (MS). Neurodegeneration is key, but myelin measures offer insights after inflammatory events.

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Area of Science:

  • Neuroscience
  • Radiology
  • Ophthalmology

Background:

  • Multiple Sclerosis (MS) presents complex functional deficits.
  • Current neuroimaging lacks a comprehensive marker for MS functional impairment.
  • Identifying reliable imaging biomarkers is crucial for clinical trials.

Purpose of the Study:

  • To determine which imaging metrics best represent functional visual impairment in MS.
  • To model the relationship between imaging data and visual function in MS patients.
  • To assess the utility of multiparametric MRI and OCT for monitoring MS progression.

Main Methods:

  • Analysis of baseline data from 50 MS patients in the prospective ReBUILD trial.
  • Utilized 3T MRI (including Neurite Orientation Dispersion and Density Imaging - NODDI) and Optical Coherence Tomography (OCT).
  • Assessed visual function using low-contrast letter acuity and employed partial least squares regression to model data.

Main Results:

  • Neurodegeneration measures along the visual pathway explained most variance in visual disability (low-contrast letter acuity).
  • In patients with a history of optic neuritis (ON), myelin measures correlated with visual performance.
  • Residual disability correlates with neurodegeneration in the absence of inflammation, while myelin measures are informative after exacerbations.

Conclusions:

  • Multiparametric MRI and OCT can model MS-associated visual impairment.
  • Neurodegeneration is a primary correlate of visual disability in MS.
  • Myelin quantification provides additional information on visual function following inflammatory events in MS.