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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Th2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis
Ying Zheng1, Lei Chai2, Yanhui Fan3,4
1Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Journal of Leukocyte Biology
|August 4, 2020
Summary
Genetic variations in T helper 2 (Th2) cell genes, specifically CTLA4 and IL6, are linked to periodontitis risk. This study identified specific single nucleotide polymorphisms (SNPs) and haplotypes associated with the disease in a Chinese population.
Area of Science:
- Immunogenetics
- Periodontal disease research
- Molecular biology
Background:
- Periodontitis is a complex inflammatory disease influenced by genetic factors.
- T helper 2 (Th2) cells play a role in immune responses and inflammation.
- Genetic polymorphisms in immune-related genes may affect susceptibility to periodontitis.
Purpose of the Study:
- To investigate the association between genetic polymorphisms of Th2 cell regulatory and effector molecules and periodontitis.
- To identify specific single nucleotide polymorphisms (SNPs) and haplotypes linked to periodontitis risk.
Main Methods:
- Genotyping of 130 SNPs across 11 Th2-related genes (e.g., CTLA4, IL6) in Chinese non-smokers using Sequenom iPlex assays.
- Cross-sectional study comparing periodontitis patients and controls.
- Meta-analysis of identified SNPs to confirm associations.
Main Results:
- A CTLA4 haplotype (GTT) was significantly associated with periodontitis.
- Meta-analysis revealed significant associations between periodontitis and allele T of CTLA4 rs5742909 (OR=1.44) and allele G of IL6 rs1800796 (OR=1.30).
Conclusions:
- Genetic variations in CTLA4 and IL6 may contribute to periodontitis susceptibility.
- Specific CTLA4 haplotypes and SNPs in CTLA4 and IL6 are potential biomarkers for periodontitis risk.
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