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    Area of Science:

    • Magnetic Resonance Imaging
    • Nuclear Magnetic Resonance Spectroscopy

    Background:

    • Most MRI scanners are designed for proton (1H) reception, limiting multi-channel array use for other nuclei.
    • Non-1H nuclei have low sensitivity, yet could greatly benefit from the SNR gains offered by array coils.
    • Broadband array receivers for non-1H nuclei are scarce, hindering their application.

    Purpose of the Study:

    • To present a cost-effective method for adapting standard 1H multi-channel array receivers for non-1H nuclei, specifically 13C.
    • To enable the use of receive arrays for in vivo multi-nuclear Nuclear Magnetic Resonance (NMR).

    Main Methods:

    • Development of a frequency translation system using active mixers within the magnet bore.
    • Conversion of non-1H array signals to the 1H frequency for host system reception.
    • Demonstration at 4.7T and 7T field strengths.

    Main Results:

    • Successful adaptation of 1H receivers for other nuclei, including 13C.
    • Preservation of signal-to-noise ratio (SNR) and channel isolation.
    • Straightforward accommodation of 1H decoupling, crucial for 13C detection.

    Conclusions:

    • Frequency translation effectively converts 1H-only multi-channel receivers for broader nuclear applications.
    • This technology maintains critical SNR and isolation while enabling essential 1H decoupling.
    • The approach facilitates the use of existing multi-channel MRI hardware for advanced in vivo multi-nuclear NMR studies.