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Related Experiment Video

Updated: Dec 13, 2025

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation
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Stereotactic Transcranial Focused Ultrasound Targeting System for Murine Brain Models.

Sang Won Choi, Tyler I Gerhardson, Sarah E Duclos

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |August 4, 2020
    PubMed
    Summary

    This study presents an affordable, precise focused ultrasound stereotactic targeting system for mouse brain models using MRI guidance. The system achieved high accuracy in targeting glioblastoma tumors in vivo.

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    Area of Science:

    • Biomedical Engineering
    • Neurosurgery
    • Medical Imaging

    Background:

    • Focused ultrasound (FUS) offers non-invasive therapeutic potential for brain conditions.
    • Accurate targeting is crucial for FUS efficacy, especially in small animal models.
    • Existing stereotactic methods may lack precision or be cost-prohibitive for extensive research.

    Purpose of the Study:

    • To develop and validate an inexpensive, MRI-guided focused ultrasound stereotactic targeting system for murine brain models.
    • To quantify the targeting accuracy of the system in phantom and in vivo studies.

    Main Methods:

    • A focused ultrasound stereotactic system was designed and its components analyzed for uncertainty.
    • The system underwent calibration using clot phantoms.
    • Targeting accuracy was assessed using pre- and post-treatment MRI in a mouse glioblastoma (GBM) model.

    Main Results:

    • Pre- and post-calibration phantom studies showed significant reduction in targeting error.
    • The calibrated system achieved minimal residual errors in axial, lateral, and elevational axes.
    • In vivo studies on GBM-bearing mice demonstrated high targeting accuracy with reduced error.

    Conclusions:

    • The developed focused ultrasound stereotactic system is accurate and cost-effective for murine brain research.
    • This method enables precise FUS application in small animal models for studying brain diseases like glioblastoma.