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Relationship between hemoglobin and insulin-like growth factor-1 in children and adolescents with idiopathic short

Qianqian Zhao1,2, Mei Zhang1,2, Baolan Ji1,2

  • 1Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, Shandong, 272029, P.R. China.

BMC Endocrine Disorders
|August 5, 2020
PubMed

Insights

Hemoglobin (Hb) levels are linked to insulin-like growth factor-1 (IGF-1) in children with idiopathic short stature (ISS). IGF-1 rises with Hb, but declines after Hb exceeds a specific threshold.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Axis
  • Hematology

Background:

  • The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis is crucial for child development.
  • Idiopathic short stature (ISS) is often associated with low serum IGF-1 levels despite normal GH.
  • Underlying factors for low IGF-1 in ISS remain largely unknown.

Purpose of the Study:

  • To investigate the relationship between hemoglobin (Hb) and IGF-1 in children and adolescents diagnosed with ISS.
  • To identify potential correlations between hematological parameters and growth factors in pediatric short stature.

Main Methods:

  • Cross-sectional analysis of 178 children and adolescents with ISS (March 2013 - February 2019).
  • Evaluation of clinical and biochemical parameters, including Hb and IGF-1 standard deviation scores (SDS).
  • Application of univariate analysis, smooth curve fitting, and multivariate piecewise linear regression.

Main Results:

  • A significant positive association was observed between Hb and IGF-1 SDS (P < 0.001) in univariate analysis.
  • This positive correlation persisted after adjusting for confounding factors (P = 0.001).
  • A piecewise linear regression revealed an inflection point at 145 g/L Hb; IGF-1 SDS increased with Hb below this point but decreased with Hb above it.

Conclusions:

  • Hemoglobin (Hb) is significantly associated with insulin-like growth factor-1 (IGF-1) in Chinese children and adolescents with idiopathic short stature (ISS).
  • IGF-1 levels initially rise with increasing Hb concentrations.
  • However, beyond a specific Hb threshold (145 g/L), elevated Hb levels correlate with decreased IGF-1.
Abstract

Keywords:
HemoglobinIdiopathic short statureInsulin-like growth factor-1

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