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Published on: December 15, 2011
5HT expression in the stomach and duodenum of the Rhesus Monkey (Macaca mulatta)
B G de Luca1, A L Bastos1, A S F da S Souza2
1Laboratory of Teaching and Research in Histology and Comparative Embryology (LEPHEC), Federal Fluminense University, Niterói, RJ, Brazil.
This study details the histology of Rhesus monkey gastric and duodenal mucosa, mapping the distribution of serotonin (5-HT) cells across different regions. Serotonin cells are most frequent in the cardia and duodenum, and least in the pylorus.
Area of Science:
- Gastroenterology
- Histology
- Primate research
Background:
- The gastric and duodenal mucosa's histological features are crucial for understanding digestive functions.
- Serotonin (5-HT) plays a significant role in gastrointestinal physiology and pathophysiology.
Purpose of the Study:
- To histologically describe Rhesus monkey gastric and duodenal mucosa.
- To analyze the distribution and relative frequency of serotonin (5-HT) cells in these regions.
Main Methods:
- Histological examination of Rhesus monkey gastric and duodenal tissues.
- Identification and quantification of 5-HT cells using immunohistochemistry (implied).
- Analysis of cell distribution in cardia, body, fundus, pylorus, and duodenum.
Main Results:
- Cardia mucosa: simple columnar epithelium, 5-HT cells at gland base (8.72 ± 4.98 cells/mm²).
- Body mucosa: fewer glands, 5-HT cells predominantly at gland base (6.96 ± 3.81 cells/mm²).
- Fundus mucosa: smaller pits, 5-HT cells at gland base (5.29 ± 2.09 cells/mm²).
- Pylorus mucosa: deep pits, scarce 5-HT cells at gland base (1.18 ± 1.36 cells/mm²).
- Duodenum: goblet cells, 5-HT cells in lining epithelium and glands (8.16 ± 2.59 cells/mm²).
Conclusions:
- Significant regional variations in 5-HT cell distribution exist within the Rhesus monkey stomach and duodenum.
- The duodenum and cardia exhibit the highest densities of 5-HT cells, suggesting region-specific roles.
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