Harnessing biomolecules for bioinspired dental biomaterials

Area of Science:

• Biomaterials Science
• Dental Research
• Regenerative Medicine

Background:

• Traditional dental materials (polymers, ceramics, metals, composites) have limitations in clinical outcomes.
• Intense research on conventional materials has not fully resolved poor clinical results for crucial dental therapies.
• Biomolecules are emerging as a promising alternative chassis for dental applications.

Purpose of the Study:

• To review biomolecules used in dental biomaterials.
• To focus on the biological activity of biomolecules for disease prevention and oral health restoration.
• To analyze structure-function relationships and advantages of biomolecules over conventional therapies.

Main Methods:

• Narrative review of biomolecules in dental biomaterials.
• Focus on biological activity, structure-function relationships, and clinical challenges.
• Exclusion of biomaterials for bone regeneration due to existing reviews.

Main Results:

• Biomolecules provide versatile and precise tools for bioinspired, multifunctional dental materials.
• Key biological activities include prevention of oral diseases and restoration of oral health.
• Structure-function relationships dictate biological efficacy for specific clinical conditions.

Conclusions:

• Biomolecules represent a significant advancement in dental biomaterials.
• Future innovations lie in harnessing biomolecules for enhanced patient oral care.
• Further research into biomolecule-based materials promises improved dental therapies.