Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Side Effects of First-Line Anti-tubercular Therapy (ATT): Does an Alternative Regimen Exist?

Cureus·2026
Same author

Association of type 2 diabetes and osteoarthritis: an umbrella review of systematic reviews and meta-analyses.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2025
Same author

Evaluation of chronic perilunate dislocations: A comparative study of single-stage, two-stage ORIF, and salvage procedures.

Injury·2024
Same author

Sciatic nerve palsy after direct anterior approach for total hip replacement.

BMJ case reports·2023
Same author

Single-stage long-stem total knee arthroplasty in severe arthritis with stress fracture: a systematic review.

Knee surgery & related research·2023
Same author

Mesenchymal stromal cell therapy for patients with rheumatoid arthritis.

Experimental cell research·2023

Related Experiment Video

Updated: Dec 13, 2025

Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery
09:13

Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery

Published on: October 6, 2022

3.8K

Flexor tendon repair with amniotic membrane.

Saket Prakash1, Pulkit Kalra1, Anil Dhal2

  • 1Department of Orthopaedics, Maulana Azad Medical College & Lok Nayak Hospital, New Delhi, India.

International Orthopaedics
|August 5, 2020
PubMed
Summary

Human amniotic membrane (HAM) wrap reduced flexor tendon adhesion and inflammation after surgical repair. This innovative technique improved patient outcomes, including less pain and better tendon healing.

Keywords:
Flexor tendonHigh-frequency ultrasoundHuman amniotic membraneInterleukin-6TGF-beta-1

More Related Videos

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
06:36

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

Published on: December 10, 2021

3.2K
Murine Flexor Tendon Injury and Repair Surgery
07:32

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

13.5K

Related Experiment Videos

Last Updated: Dec 13, 2025

Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery
09:13

Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery

Published on: October 6, 2022

3.8K
A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
06:36

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

Published on: December 10, 2021

3.2K
Murine Flexor Tendon Injury and Repair Surgery
07:32

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

13.5K

Area of Science:

  • Regenerative Medicine
  • Orthopedic Surgery
  • Biomaterials Science

Background:

  • Tendon adhesion is a common complication following flexor tendon repair, leading to impaired function.
  • Fibrotic responses and inflammation contribute significantly to post-surgical adhesions.
  • Current methods for preventing adhesion have limitations.

Purpose of the Study:

  • To evaluate the efficacy of human amniotic membrane (HAM) in reducing fibrotic response and tendon adhesion after flexor tendon repair.
  • To assess the impact of HAM wrap on clinical outcomes and biologic response.

Main Methods:

  • A prospective study involving 19 patients with flexor tendon injuries.
  • Surgical repair with HAM wrap in 9 patients (case group) and without HAM wrap in 10 patients (control group).
  • Clinical assessment included pain, range of motion, pinch strength; ultrasound evaluated tendon healing; serum markers measured inflammation (IL-6, TGF-beta-1).

Main Results:

  • HAM wrap group showed reduced pain, improved range of motion, and better tendon glide on ultrasound.
  • Serum inflammatory markers decreased in the HAM group, while they increased in the control group.
  • No adverse events like infection or immune rejection were observed with HAM application.

Conclusions:

  • Human amniotic membrane wrap promotes faster functional recovery and superior tendon healing post-repair.
  • HAM effectively mitigates the biologic response, reducing inflammation and adhesion formation.
  • HAM represents a promising biomaterial for enhancing outcomes in flexor tendon repair surgery.