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Updated: Dec 13, 2025

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
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Nanotechnology-based antiviral therapeutics.

Malobika Chakravarty1, Amisha Vora2

  • 1Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, 400056, India.

Drug Delivery and Translational Research
|August 5, 2020
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Summary

Nanotechnology offers advanced solutions for viral infections, overcoming traditional medicine limitations. This approach enhances drug delivery and potency against viruses like influenza, HIV, and coronaviruses.

Keywords:
Antiviral therapyNanotechnologyNanovaccinesViral infections

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Area of Science:

  • * Virology and Nanomedicine: Interdisciplinary research at the intersection of viral disease mechanisms and nanotechnology applications.
  • * Drug Delivery Systems: Focus on advanced nanomaterials for targeted antiviral therapy.

Background:

  • * Viral infections compromise the host immune system, leading to frequent relapses and therapeutic challenges.
  • * Viruses destroy host cells, necessitating novel strategies beyond conventional antiviral drugs.
  • * Limitations of traditional antiviral medicines include issues with drug solubility and toxicity.

Purpose of the Study:

  • * To explore the potential of nanotechnology in combating viral infections.
  • * To review various nanomaterials as drug delivery vehicles for antiviral therapeutics.
  • * To highlight emerging nanotechnology-based treatment modalities for viral diseases.

Main Methods:

  • * Analysis of key viral and host cell proteins involved in viral entry and replication for influenza, Ebola, HIV, herpes, Zika, dengue, and coronaviruses.
  • * Review of diverse nanomaterial types (lipid-based, polymer-based, carbon-based, inorganic metal-based, etc.) used as antiviral drug delivery systems.
  • * Inclusion of recent advancements in nanotechnology for COVID-19 treatment.

Main Results:

  • * Nanotechnology effectively addresses limitations of traditional antiviral drugs, improving solubility and reducing toxicity.
  • * Nanomaterials enhance drug potency and selectivity towards viral cells.
  • * Various nanomaterials demonstrate significant potential as effective antiviral drug delivery vehicles.

Conclusions:

  • * Nanotechnology presents a promising frontier for developing effective antiviral therapeutics.
  • * Emerging approaches like nanotraps, nanorobots, and nanovaccines offer novel treatment strategies.
  • * Continued research in nanotechnology is crucial for managing current and future viral pandemics.