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Updated: Dec 13, 2025

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
[Interventional endoscopy in the gastrointestinal tract : Indications and limitations]
M Hollenbach1, J Feisthammel2, A Hoffmeister2
1Bereich Gastroenterologie, Klinik für Onkologie, Gastroenterologie, Hepatologie, Pneumologie und Infektiologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Deutschland. marcus.hollenbach@web.de.
Endoscopic techniques now offer minimally invasive treatments for gastrointestinal lesions and complications, including advanced resection methods and submucosal tunnel techniques for conditions like achalasia.
Area of Science:
- Gastroenterology and Endoscopy
Background:
- Endoscopic techniques have significantly advanced, expanding treatment options beyond traditional surgery.
- Many gastrointestinal lesions and complications previously requiring surgery can now be managed endoscopically.
Purpose of the Study:
- To present and critically evaluate interventional endoscopic techniques.
- To highlight recent advancements in endoscopic mucosal resection, submucosal dissection, and full-thickness resection.
Main Methods:
- Review of advanced endoscopic techniques including endoscopic mucosal resection (EMR), submucosal dissection (SMD), and full-thickness resection.
- Discussion of submucosal tunnel creation for lesion excision and achalasia treatment.
- Evaluation of endosonography-guided interventions and cholangioscopy for pancreatic and biliary duct issues.
Main Results:
- Endoscopic mucosal resection and submucosal dissection allow for the resection of large or laterally spreading polyps.
- Full-thickness resection is achievable with specialized clips.
- Submucosal tunnel techniques enable complete excision of submucosal lesions and endoscopic myotomy for achalasia.
- Endosonography and cholangioscopy provide new therapeutic avenues for pancreatic and biliary diseases.
Conclusions:
- Interventional endoscopy has broadened its scope, offering less invasive solutions for a range of gastrointestinal conditions.
- These advanced endoscopic techniques provide effective alternatives to surgery for various lesions and complications.
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